The in promoting tumor cell migration and angiogenesis.
The environmental riskfactors predisposing to NAFLD are mainly represented by a diet rich insaturated fatty acids, low physical activity and the intestinal bacterialovergrowth. On the other hand, environmental factors predisposing to NAFLDrequire a genetic predisposition. Patatin-LikePhospholipase domain containing 3 (PNPLA3) or Adiponutrin is highlyexpressed in the liver and it is thought that the I148M SNP is closelyassociated with liver fat content and serum amino transferase. The mutation canreduce the activity of adiponutrin, a triacylglycerol lipase that mediatestriacyglycerol hydrolysis in adipocytes. Of note, asignificant proportion of people have both metabolic syndrome and the G allele,and over 70% of these individuals have […]