Mast cells mediate inflammatory responses such as hypersensitivity and allergic reactions. They are scattered throughout the connective tissues of the body beneath the surface of the skin, near blood vessels and lymphatic vessels and within nerves. Mast cells store a number of different chemical mediators including histamine, interleukins, proteoglycans. The chemical mediators produce local responses characteristic of an allergic reaction such as inflammation and swelling. (The Editors of Encyclopedia Britannica, Mast Cell, Encyclopedia Britannica, March 23, 2016, December 11.) 2017, https://www.britannica.com/science/mast-cell Natural killer cells contain granules that house cytotoxic chemicals. Natural killer cells recognise dividing cells. They then bind to these dividing cells and insert their granules through the outer membrane and into the cytoplasm. This causes the dividing cells to leak and die. (The Editors of Encyclopædia Britannica, NK Cell Encyclopedia Britannica, March 23, 2016, December 11.) 2017, https://www.britannica.com/science/immune-system Macrophages. They are large irregular shaped cells with granules in the cytoplasm. They are actively phagocytic engulfing and digesting cell debris, bacteria and other foreign bodies. Their role can be found in the form of monocytes in the blood. (Waugh & Grant, Anatomy and Physiology, 12th Ed, 2014, P.40.) Dendritic cells are central to the initiation of primary immune responses. They are the only antigen-presenting cell capable of stimulating naive T cells. Dendritic cells are pivotal in the generation of adaptive immunity. Dendritic cells interact and influence the response of cells of the innate immune system. (Howard, C., Charleston, B., Stephens, S., Sopp, P., & Hope, J. (2004). The role of dendritic cells in shaping the immune response. Animal Health Research Reviews, December 2017) 

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