One of the most valuable components of indigenous medical systems for over 40 centuries has been Mangifera indica leaves, the largest fruit-bearing tree ever discovered in India. Mangifera leaves usage as a medical agent dates back to 327 BCE. Existence of prime groups of phytochemical constituents such as anthraquinones, saponins, terpenoids, etc. and therapeutically active components such as mangiferin, friedelin, stigmasterol, lupeol, etc. was also claimed to be found in Mangifera indica leaves Although the scientific information that can support its success is scarce, the leaves have been traditionally used as an antibacterial and immunomodulatory agent. Nigerian Folk herbalism also uses Mangifera indica leaves as an anti-bacterial agent. To find out whether or not there is a scientific basis for this usage, blood glucose level effectivity was evaluated in normoglycaemic, glucose-induced hyperglycaemic and streptozotocin (STZ) induced diabetic rodents, such as a Rattus (rat). The orally given aqueous extract, however, did not modify the blood glucose levels in either normoglycaemic or STZ-induced (streptozotocin) diabetic rodents, specifically Rattus (rat). Aqueous extracts of Mangifera indica leaves showed remarkable influence on reproductive functions, wound regeneration and antidiabetic tasks. Alcoholic extracts of Mangifera indica leaves have been found containing TNF- (Tumor necrosis factor), ILIB expression and B-lactamase producing enteric bacterial development. Mangifera indica leaves are also equipped with a broad outer cuticle to avoid the loss of nutrients and to prevent wetting when it’s raining. Furthermore, Mangifera indica leaves are found alternating on the plant stalk to exploit the light energy acquired from the sun. This might be because of the fact that Mangifera leaves works best when in direct exposure to sunlight.The Mangifera indica leaves contains group of phytochemical such as saponins anthraquinones, terpenoids and therapeutically active components such as mangiferine, stigmasterol, triedelin, lupeol. It has been used as an antibacterial agent in nigeria.The leaves extracts has significant activities or reproductive functions. It heals wound and has antidiabetic activities. The alchoholic extracts inhibits TNF and ILIB expression and B. Lactamase producing bacterial growth. The leaves has a thick outer cuticle that prevent lost of nutrients and wetting when it’s raining and it is also found alternating or the plant stem to minimize light energy coming from the sun, due to the fact that mangifera indica grow best in full expose to sunlight.