Oros orifice at a rate, which is precisely controlled,
Oros Colon Targeting: Components 1. Semipermeable membrane 2. Hard gelatin capsule Working This has one osmoticagent or it comprises ofas many as 5 tosi6 push pull osmotic unit occupied in a hardgelatin capsule. After next inassociation with the aqueous surroundings, gelatin capsule dissolved (liquefy) and the enteric coatingavoids entry of extracts from stomach to thesystem, when system permit into the small intestine the enteric coating dissolves and water is absorbed into the core thus affecting the push compartment to swell. At the same time flow-able gel is formed in thedrug compartment, which is pushed out of the orifice at a rate, which is precisely controlled, by the rate of water transport crossways the semi permeable membrane Advantage It is used as a one or twotimes a day formulation for site exact delivery of drugs to the colon. Monolithicosmotic system: Components 1. Polymer matrix capsule 2. […]
